Yes. That's what we're predicting. By "we," I don't just mean liberals, I mean people like Virginia Attorney General Ken Cuccinelli who are focusing on Justice Anthony Kennedy as the one person whose vote needs to be won. They wouldn't be fighting this battle if they didn't think they could win it.Really? I can think of quite a few reasons that Cuccinelli and other Republicans would fight this battle even if they thought it was hopeless. For one thing, there's the Tea Party approval for every step of it, from the initial decision to file the suit, to actually filing it, to arguing it, to the appeals...for a state AG, that's a lot of great media hits. For another, it allows Republicans to fight on territory they're real comfortable with ("tyranny"), as opposed to having to get down into the complex issues surrounding health care. Plus it gives conservatives, especially if they lose, an excuse to focus on one of their very favorite themes, court bashing.
Generally, there are usually lots of incentives for politicians to fight hopeless fights. They get all the publicity and none of the responsibility. Hopeless court fights are great, because they promise to stretch out for years, with no obligation to put together complex legislation (which could actually harm their constituents if enacted), or deal with the consequences of a victory.
I'll add one thing: while I again won't make any prediction about the outcome, I'll point out that everyone involved has a strong incentive to act as if the lawsuit has a good chance of winning. For Republicans, the whole point is lost if people don't take it seriously. For Democrats, it's a good chance to raise money off of the fear that a future president and Senate will undermine the post-New Deal constitutional order. Hey, even pundits are implicated. Tribe notwithstanding, the odds are that those who don't think there's a real possibility that the court could toss out part or all of ACA just won't write about it, while those who do think it's likely will.
Anyway, the main point here is that hopeless fights are often a politician's best friend. Especially those not especially interested in governing.