Acrossappears to be "CZAR." As I said last time, really? I mean, it's an awful definition...a tiny handful of all (American, presidential) political appointees are sometimes called "czars," and I do believe that there are quite a few non-governmental jobs that get the nickname "czar" (i.e. supply closet czar) despite not being political appointees. Not to mention those old Russian dudes. I don't know...perhaps I'm seeing right-wing crazy when I'm really just peeved at a poor clue, but I'll certainly be watching out for, oh, I don't know...
50. Political appointee
Death ____ (six letters)
Presidential birthplace (five letters)
Fair and balanced network (three letters)
And of course,
Smartest investment (four letters)